In December of 1973, the West Palm Beach Alumnae Chapter of Delta Sigma Theta Sorority, Inc., under the direction of Soror Eva W. Mack, sponsored a sickle cell screening and counseling program for high school students in Palm Beach County. This program was only funded for one year, and additional funding was not available to continue the program.
In 1976, Delta Sigma Theta Sorority, Inc. adopted the sickle cell screening and counseling program as one of its projects and chartered the Delta Sigma Theta Sickle Cell Foundation of Palm Beach County. By 1978 there were several organizations in the County, operating independently, with sickle cell as their interest. Realizing the increased advantages of a combined coordinated effort, the Delta Sigma Theta Sickle Cell Foundation, along with the other interested groups that included the Number One Travelers, The CIBS Club, The Eldorado Civic Club, Florida A&M Alumni Association and Glades Chapter of Delta Sigma Theta Sorority, organized an embryo organization: Sickle Cell Foundation of Palm Beach County.
In 1979, the organization obtained a charter under the same name and was granted incorporation status. Prompted by a name change of the national organization, the Foundation became Sickle Cell Disease Association of America Palm Beach County Chapter, Inc. in 1994. In November of 1999, the organization reverted to its original name of SICKLE CELL FOUNDATION OF PALM BEACH COUNTY by action of the Board of Directors. To more accurately reflect the geographical area served, the name was changed in January of 2008 to SICKLE CELL FOUNDATION OF PALM BEACH COUNTY AND TREASURE COAST, INC.